Antineoplastic Agents. 603. Quinstatins: Exceptional Cancer Cell Growth Inhibitors

Mechanism-Based Inhibitors of Deoxythymidine Monophosphate Synthesis as Antineoplastic Agents

INTRODUCTION 5-Fluorouracil and methotrexate are antimetabolites widely used in the treatment of neoplastic disease. They act by inactivating the two enzymes involved in the biosynthesis of the pyrimidine nucleotide 2’-deoxythymidine 5’-monophosphate, namely thymidylate synthase and dihydrofolate reductase. The three dimensional structure of each enzyme is known and the mechanisms of the reacti...

Antineoplastic Agents

Pharmacology of Antineoplastic Agents in Older Cancer Patients

People over the age of 65 are a fast-growing segment of the US population, and with the incidence of cancer increasing with age, the challenges of treating older cancer patients are also on the rise. Drs. Lichtman and Skirvin present a comprehensive review of the antineoplastic agents used in elderly cancer patients. They highlight the important factors of chemotherapy pharmacology in elderly c...

Pharmacology of antineoplastic agents in older cancer patients.

Persons over the age of 65 years are the fastest growing segment of the United States population. In the next 30 years it will comprise over 20% of the population. Fifty percent of all cancers occur in this age group and therefore there will be an expected rise in the total cancer burden. Data is becoming available which will better guide the use of chemotherapy in the older patient population....

Cell Cycle Inhibitors as Breast Cancer Prevention Agents